APOBEC3B deletion and risk of HIV-1 acquisition.
retrospective_cohort · Level III
Where this comes from
- Record sourced from PubMed, PMID 19698078.
- Also identified by DOI 10.1086/605644 and PMC identifier 3690486.
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Abstract
The human APOBEC3 family of cytidine deaminases provides intrinsic immunity to retroviral infection. A naturally occurring 29.5-kb deletion removes the entire APOBEC3B gene. We examined the impact of the APOBEC3B gene deletion in >4000 individuals from 5 human immunodeficiency virus type 1 (HIV-1) natural history cohorts. The hemizygous genotype had no effect on either acquisition of HIV-1 infection or progression to AIDS. However, the homozygous deletion was significantly associated with unfavorable outcomes for HIV-1 acquisition (odds ratio, 7.37; P= .024), progression to AIDS (relative hazard, 4.01; P=. 03), and viral set point (P= .04). These findings suggest that the loss of APOBEC3B may increase host susceptibility to HIV-1 acquisition and progression to AIDS and warrant further study.
Medical subject headings
- Cytidine Deaminase
- Genetic Predisposition to Disease
- HIV Infections
- HIV-1