Abnormalities of T cell immunoregulation in hemorrhagic fever with renal syndrome.
case_control · Level III
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Abstract
The functions of spontaneous suppressor T cells and T lymphocyte subsets in patients with hemorrhagic fever with renal syndrome were compared. In the early stages of disease, decreased activity of spontaneous suppressor T cells was concurrent with increased numbers of CD8+ cells and a reversed CD4:CD8 ratio. These changes were related to abnormalities in serum C3 level and circulating immune complexes. In the recovery stages of the illness, spontaneous suppressor T cell activity and T cell subsets returned to normal levels.
Medical subject headings
- Hemorrhagic Fever with Renal Syndrome
- T-Lymphocytes
- T-Lymphocytes, Regulatory