ErythRED, a hESC line enabling identification of erythroid cells.
basic_science · Level V
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- Record sourced from PubMed, PMID 19701193.
- Also identified by DOI 10.1038/nmeth.1364.
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Abstract
A human embryonic stem cell (hESC) line that enabled globin-expressing cells to be easily recognized would facilitate optimization of erythroid differentiation in vitro and aid in the identification of hESC-derived erythroid cells in transplanted animals. We describe a genetically modified hESC line, ErythRED, in which expression of RFP, controlled by regulatory sequences from the human beta-globin locus control region, is restricted to maturing erythroid cells.
Medical subject headings
- Embryonic Stem Cells
- Erythroid Cells