Only two ways to achieve perfection.

Artyukhin, Alexander B; Wu, Lani F; Altschuler, Steven J · Cell · 2009

basic_science · Level V

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Abstract

The functional repertoire of a network is determined by its topology. Ma et al. (2009) analyze enzyme networks with three nodes and take a reverse-engineering approach to ask how many core network topologies can establish perfect adaptation, the ability to reset after perturbation. Surprisingly, the answer is just two.

Medical subject headings