Clamping down on transposon targeting.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19703389.
- Also identified by DOI 10.1016/j.cell.2009.08.003.
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Abstract
The sliding beta clamp subunit of the DNA replication machinery in the bacterium Escherichia coli coordinates multiple functions in the cell beyond genome duplication. In this issue, Parks et al. (2009) find that the beta clamp interacts with the transposition protein TnsE to target the Tn7 transposon to discontinuously replicating DNA at the replication fork.
Medical subject headings
- DNA Replication
- DNA Transposable Elements
- Escherichia coli