Breast cancer stem cells: eradication by differentiation therapy?
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19703390.
- Also identified by DOI 10.1016/j.cell.2009.08.007.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
During metastasis, migrating breast cancer stem cells undergo a loss of polarity leading to an epithelial-to-mesenchymal transition (EMT). Gupta et al. (2009) use this attribute of cancer stem cells to develop a high-throughput screen, which successfully identifies small molecules that specifically inhibit cancer stem cell proliferation through the induction of differentiation.
Medical subject headings
- Breast Neoplasms
- Cell Differentiation
- Neoplastic Stem Cells