Genome-wide location analysis reveals a role for Sub1 in RNA polymerase III transcription.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19706510.
- Also identified by DOI 10.1073/pnas.0900162106 and PMC identifier 2725013.
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Abstract
Human PC4 and the yeast ortholog Sub1 have multiple functions in RNA polymerase II transcription. Genome-wide mapping revealed that Sub1 is present on Pol III-transcribed genes. Sub1 was found to interact with components of the Pol III transcription system and to stimulate the initiation and reinitiation steps in a system reconstituted with all recombinant factors. Sub1 was required for optimal Pol III gene transcription in exponentially growing cells.
Medical subject headings
- DNA-Binding Proteins
- RNA Polymerase III
- Saccharomyces cerevisiae Proteins
- Transcription Factors
- Transcription, Genetic