Pharmacokinetics of moxifloxacin in cerebrospinal fluid and plasma in patients with tuberculous meningitis.
case_series · Level IV
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- Record sourced from PubMed, PMID 19712035.
- Also identified by DOI 10.1086/605576.
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Abstract
Moxifloxacin cerebrospinal fluid (CSF) penetration was evaluated by obtaining full plasma and CSF time concentration curves for 4 patients with tuberculous meningitis. The geometric mean ratio of the areas under the curve for CSF to plasma were 0.82 (range, 0.70-0.94) at 400 mg once per day and 0.71 (0.58-0.84) at 800 mg once per day.
Medical subject headings
- Antitubercular Agents
- Aza Compounds
- Cerebrospinal Fluid
- Plasma
- Quinolines
- Tuberculosis, Meningeal