A multi-institutional acute gastrointestinal toxicity analysis of anal cancer patients treated with concurrent intensity-modulated radiation therapy (IMRT) and chemotherapy.

Devisetty, Kiran; Mell, Loren K; Salama, Joseph K; Schomas, David A; Miller, Robert C; Jani, Ashesh B; Roeske, John C; Aydogan, Bulent et al. · Radiother Oncol · 2009

retrospective_cohort · Level III

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Abstract

Using previous dosimetric analysis methods, we identified the volume of bowel receiving 30 Gy (V(30)) correlated with acute gastrointestinal (GI) toxicity in anal cancer patients treated with intensity-modulated radiation therapy and concurrent chemotherapy. For V(30)>450 cc and < or =450 cc, acute GI toxicity was 33% and 8%, respectively (p=0.003).

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