Generation of pluripotent stem cells from patients with type 1 diabetes.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19720998.
- Also identified by DOI 10.1073/pnas.0906894106 and PMC identifier 2735559.
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Abstract
Type 1 diabetes (T1D) is the result of an autoimmune destruction of pancreatic beta cells. The cellular and molecular defects that cause the disease remain unknown. Pluripotent cells generated from patients with T1D would be useful for disease modeling. We show here that induced pluripotent stem (iPS) cells can be generated from patients with T1D by reprogramming their adult fibroblasts with three transcription factors (OCT4, SOX2, KLF4). T1D-specific iPS cells, termed DiPS cells, have the hallmarks of pluripotency and can be differentiated into insulin-producing cells. These results are a step toward using DiPS cells in T1D disease modeling, as well as for cell replacement therapy.
Medical subject headings
- Adult Stem Cells
- Diabetes Mellitus, Type 1
- Pluripotent Stem Cells