Alterations of "sleeping time" in the rat induced by drugs which modulate central monoaminergic systems.
basic_science · Level V
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Abstract
The effects of adrenoceptor agonists and antagonists have been determined on "sleeping time" in the rat--that is, with the animal immobile and adopting a sleeping posture. Alterations in their gross behaviour patterns were assessed also. The specific alpha 2-adrenoceptor agonists (yohimbine, WY 26393, RX 781094 and RS 21361) decreased sleeping time, as did the beta-adrenoceptor agonist clenbuterol. The specific alpha 2-adrenoceptor agonist clonidine gave a large increase in sleeping time at doses in excess of 25 micrograms kg-1. The same effect was seen with the beta-antagonist propranolol and the specific beta 2-antagonist ICI 118551.
Medical subject headings
- Sleep
- Sympatholytics
- Sympathomimetics