Getting a "Hold" on NPC2.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 19723490.
- Also identified by DOI 10.1016/j.cmet.2009.08.006.
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Abstract
Lipoprotein cholesterol is mobilized from lysosomes by actions of the NPC1 and NPC2 proteins. In this issue of Cell Metabolism, Harrison et al. report on identification of an NPC2-interacting protein, the Nogo-B receptor, that regulates NPC2 protein levels. NPC2 stabilization may represent a novel mechanism through which cells respond to endocytosed cholesterol.
Medical subject headings
- Carrier Proteins
- Glycoproteins