Getting to the root of BRCA1-deficient breast cancer.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19733528.
- Also identified by DOI 10.1016/j.stem.2009.08.007.
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Abstract
Loss of BRCA1 has been shown to expand breast stem cells. In Nature Medicine, Lim et al. (2009) demonstrate that breast tissue from BRCA1 mutation carriers contains expanded luminal progenitor cells, suggesting a broader role for BRCA1 in mammary development.
Medical subject headings
- Animals
- BRCA1 Protein
- BRCA1 Protein/deficiency
- Breast Neoplasms
- Breast Neoplasms/genetics
- Breast Neoplasms/metabolism
- Breast Neoplasms/pathology
- Cell Differentiation
- Disease Models, Animal
- Female
- Gene Dosage
- Humans
- Mammary Glands, Human
- Mammary Glands, Human/cytology
- Mice
- Stem Cells
- Stem Cells/cytology