Growth signaling at the nexus of stem cell life and death.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 19733530.
- Also identified by DOI 10.1016/j.stem.2009.08.008 and PMC identifier 3390250.
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Abstract
Stress can activate tumor-suppressive mechanisms, causing the loss of adult stem cell function with age. In this issue of Cell Stem Cell and in Nature, Castilho et al. (2009) and Harrison et al. (2009) highlight the importance of mTOR signaling in stem cell exhaustion and mammalian aging, respectively.
Medical subject headings
- Animals
- Cell Death
- Cell Proliferation
- Cellular Senescence
- Hair Follicle
- Hair Follicle/cytology
- Hair Follicle/drug effects
- Hair Follicle/metabolism
- Mice
- Models, Biological
- Protein Kinases
- Protein Kinases/metabolism
- Signal Transduction
- Stem Cells
- Stem Cells/cytology
- Stem Cells/metabolism
- TOR Serine-Threonine Kinases
- Wnt Proteins
- Wnt Proteins/metabolism
- beta Catenin
- beta Catenin/metabolism