A magnetically triggered composite membrane for on-demand drug delivery.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19736912.
- Also identified by DOI 10.1021/nl9018935 and PMC identifier 2761986.
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Abstract
Nanocomposite membranes based on thermosensitive, poly(N-isopropylacrylamide)-based nanogels and magnetite nanoparticles have been designed to achieve "on-demand" drug delivery upon the application of an oscillating magnetic field. On-off release of sodium fluorescein over multiple magnetic cycles has been successfully demonstrated using prototype membrane-based devices. The total drug dose delivered was directly proportional to the duration of the "on" pulse. The membranes were noncytotoxic, were biocompatible, and retained their switchable flux properties after 45 days of subcutaneous implantation.
Medical subject headings
- Acrylamides
- Drug Delivery Systems
- Magnetics
- Membranes, Artificial
- Metal Nanoparticles
- Polymers