Carbon nanotubes activate blood platelets by inducing extracellular Ca2+ influx sensitive to calcium entry inhibitors.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19736974.
- Also identified by DOI 10.1021/nl901603k.
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Abstract
To elucidate a mechanism of prothrombotic effects of carbon nanotubes (CNTs), we report here that multiwalled CNTs activate blood platelets by inducing extracellular Ca(2+) influx that could be inhibited by calcium channel blockers SKF 96365 and 2-APB. We also demonstrate platelet aggregating activity of different single-walled and multiwalled CNTs. In addition, we show that CNT-induced platelet activation is associated with a marked release of platelet membrane microparticles positive for the granular secretion markers CD62P and CD63.
Medical subject headings
- Blood Platelets
- Calcium
- Calcium Channel Blockers
- Nanotubes, Carbon
- Platelet Aggregation Inhibitors