The hows and Ys of genome integrity.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 19737510.
- Also identified by DOI 10.1016/j.cell.2009.08.022.
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Abstract
Much of the Y chromosome consists of large palindromic arrays harboring genes that are critical for spermatogenesis. In this issue, Lange et al. (2009) show that although gene conversion within these arrays maintains their integrity, it also permits rare unequal sister chromatid-exchange events within palindromes that create unstable dicentric chromosomes, resulting in infertility, sex reversal, and Turner syndrome.
Medical subject headings
- Chromosomes, Human, Y