Advances in Ewing's sarcoma research: where are we now and what lies ahead?
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 19738075.
- Also identified by DOI 10.1158/0008-5472.CAN-08-4041.
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Abstract
Ewing's sarcoma family tumors (EFT) are characterized by specific chromosomal translocations, which lead to EWS/ETS transcription factors. Elucidation of EWS/ETS target gene networks within the context of other signaling pathways, together with the identification of the initiating cell, and the development of genetically engineered mice will hopefully lead to biology-based therapeutic strategies for these tumors.
Medical subject headings
- Sarcoma, Ewing