Effect of breast-feeding on antibody response to conjugate vaccine.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 1973970.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Infants were immunised at the ages of 2, 4, and 6 months with conjugate Haemophilus influenzae type b vaccine, and their responses to the vaccine were evaluated by feeding method (breast or formula). There were no significant differences between the groups in antibody levels at early ages. However the antibody levels were significantly higher in the breast-fed (57 infants) than the formula-fed group (24 infants) at 7 months (mean [SD] 29.8 [32.0] vs 17.5 [14.8] micrograms/ml) and at 12 months (55 vs 26 infants; 4.8 [4.4] vs 3.0 [2.3] micrograms/ml). These findings are strong evidence that breast-feeding enhances the active immune response in the first year of life, and therefore the feeding method must be taken into account in the evaluation of vaccine studies in infants.