Zeta-crystallin: a tale of two cells.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 19752863.
- Also identified by DOI 10.1038/ki.2009.227 and PMC identifier 2814062.
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Abstract
Szutkowska et al. demonstrate that zeta-crystallin plays an essential role in the stabilization of the Na(+)/K(+)/2Cl(-) cotransporter mRNA in the medullary thick ascending limb. However, differential effects of experiments using small interfering RNA to knock down zeta-crystallin in proximal tubule and thick ascending limb cells suggest that additional proteins must contribute to the rapid turnover and selective stabilization of the various mRNAs during metabolic acidosis.
Medical subject headings
- Acidosis
- RNA Stability
- zeta-Crystallins