Assignment of the X-linked torsion dystonia gene to Xq21 by linkage analysis.
basic_science · Level V
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Abstract
We performed linkage analysis of X-linked torsion dystonia (XLTD) in 7 Filipino families, studying DNA from a total of 36 family members (9 obligate carrier females, and 18 affected and 9 unaffected males). Application of 21 informative X chromosomal DNA sequences allowed assignment of the XLTD locus to the proximal long arm of the X chromosome (Xq21). A maximum LOD score of 3.06 at [symbol: see text] = 0.0 was obtained with DXYS2, previously assigned to Xq21.3.
Medical subject headings
- Dystonia Musculorum Deformans
- Genetic Linkage
- X Chromosome