Molecular epidemiology of Mycobacterium tuberculosis in a South African community with high HIV prevalence.
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- Record sourced from PubMed, PMID 19764885.
- Also identified by DOI 10.1086/605930 and PMC identifier 2932637.
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Abstract
To explore the relationship between human immunodeficiency virus (HIV) and Mycobacterium tuberculosis genotypes, we performed IS6110-based restriction fragment-length polymorphism analysis on M. tuberculosis culture specimens from patients with smear-positive tuberculosis in a periurban community in South Africa from 2001 through 2005. Among 151 isolates, 95 strains were identified within 26 families, with 54% clustering. HIV status was associated with W-Beijing strains (P = .009) but not with clustering per se. The high frequency of clustering suggests ongoing transmission in both HIV-negative and HIV-positive individuals in this community. The strong association between W-Beijing and HIV infection may have important implications for tuberculosis control.
Medical subject headings
- HIV Infections
- Molecular Epidemiology
- Mycobacterium tuberculosis
- Tuberculosis