Analysis of CXCL9 and CXCR3 expression in a case of intravascular large B-cell lymphoma.
case_report · Level V
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- Record sourced from PubMed, PMID 19766346.
- Also identified by DOI 10.1016/j.jaad.2009.02.007.
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Abstract
Intravascular large B-cell lymphoma is a rare disease with multiorgan involvement that also affects the skin. Skin manifestations include purpuric to red macules, plaques, or nodules with occasional edema and tenderness. We report a 68-year-old woman with bilateral leg edema and occasional high fever. A biopsy specimen from a subcutaneous nodule showed that the blood vessels in the dermis and subcutaneous tissue were filled with irregularly shaped chromatin-rich large atypical lymphocytes positive for CD20 and bcl-2, consistent with the diagnosis of intravascular large B-cell lymphoma. In addition, immunohistochemical analysis showed expression of CXCR3 in the atypical lymphocytes; its ligand, CXCL9, was detected in blood vessels. Although limited to a single case, our study could provide a possible new clue to the pathogenesis of intravascular large B-cell lymphoma by virtue of the characteristic expression of CXCL9-CXCR3.
Medical subject headings
- Chemokine CXCL9
- Lymphoma, Large B-Cell, Diffuse
- Receptors, CXCR3
- Vascular Neoplasms