Transposon silencing by piRNAs.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19766558.
- Also identified by DOI 10.1016/j.cell.2009.08.030 and PMC identifier 3244755.
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Abstract
In animal cells, small RNA molecules, called piRNAs, defend the genome against selfish DNA elements such as transposons. In this issue, Klattenhoff et al. (2009) report that an HP1 family protein, Rhino, is required for piRNA generation and transposon silencing in Drosophila germline cells. The results provide a link between heterochromatin and piRNA-mediated genome defense.
Medical subject headings
- DNA Transposable Elements
- Drosophila melanogaster
- Gene Silencing
- RNA, Small Interfering