Multidrug-resistant tuberculosis in Victoria: a 10-year review.

Abstract

OBJECTIVE: To describe demographic and clinical characteristics of patients residing in Victoria who were diagnosed with multidrug-resistant tuberculosis (MDR-TB) during the period 1 January 1998 to 31 December 2007. DESIGN, SETTING AND PATIENTS: Retrospective review of Victorian Department of Health data on laboratory-confirmed cases of MDR-TB for the period 1998-2007. MAIN OUTCOME MEASURES: Age, sex, country of birth, time between arrival in Australia and notification of TB, residency status, site of disease, and treatment period and outcome. RESULTS: From 1998 to 2007, 31 patients who resided in Victoria were diagnosed with MDR-TB. The median age of patients was 27 years, most patients were born overseas, and more than half were full-time students. The median time between arrival in Australia and notification of TB was 2 years, and 24 patients were notified to the Department within 5 years of arrival. Twenty patients had pulmonary disease; in 12 of these patients, sputum was smear-positive for acid-fast bacilli. The median treatment period for patients who completed treatment was 22 months. CONCLUSIONS: The number of patients diagnosed with MDR-TB per year increased during the period 1998-2007. If sustained, this increase will have important implications for public health policy and planning.