Multifunctional nanoparticles for combined doxorubicin and photothermal treatments.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19772302.
- Also identified by DOI 10.1021/nn900215k.
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Abstract
To facilitate combined doxorubicin and photothermal treatments, we developed doxorubicin-loaded poly(lactic-co-glycolic acid)-gold half-shell nanoparticles (DOX-loaded PLGA-Au H-S NPs) by depositing Au films on DOX-loaded PLGA NPs. As the PLGA NPs biodegraded, DOX was released, and heat was locally generated upon near-infrared (NIR) irradiation due to NIR resonance of DOX-loaded PLGA H-S NPs. Compared with chemotherapy or photothermal treatment alone, the combined treatment demonstrated a synergistic effect, resulting in higher therapeutic efficacy and shorter treatment times. Since our NPs selectively deliver both heat and drug to tumorigenic regions, they may improve the therapeutic effectiveness with minimal side effects.
Medical subject headings
- Antineoplastic Agents
- Doxorubicin
- Drug Carriers
- Hyperthermia, Induced
- Metal Nanoparticles
- Nanomedicine
- Phototherapy