Ultraviolet radiation and immunosuppression.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 19775363.
- Also identified by DOI 10.1111/j.1365-2133.2009.09455.x.
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Abstract
Ultraviolet (UV) radiation is a complete carcinogen. The effects of UV radiation are mediated via direct damage to cellular DNA in the skin and suppression of image surveillance mechanisms. In the context of organ transplantation, addiction of drugs which suppress the immune system add greatly to the carcinogenicity of UV radiation. This review considers the mechanisms of such effects.
Medical subject headings
- Apoptosis
- DNA Damage
- Immunosuppression Therapy
- Neoplasms, Radiation-Induced
- Skin
- Ultraviolet Rays