Topical chemotherapy for ocular surface squamous neoplasia: current status.

Sepulveda, Ricardo; Pe'er, Jacob; Midena, Edoardo; Seregard, Stefan; Dua, Harminder S; Singh, Arun D · Br J Ophthalmol · 2010

review · Level V

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Abstract

Although there are no randomised trials directly comparing topical chemotherapeutic agents mitomycin-C, 5-fluorouracil, and interferon-alpha2b, published studies indicate equal efficacy of these agents for treatment of non-invasive ocular surface squamous neoplasia (80%-88%). 5-Fluorouracil may be preferred, given low incidence of serious side effects and low cost to the patient.

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