p53 ancestry: gazing through an evolutionary lens.
review · Level V
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- Record sourced from PubMed, PMID 19776745.
- Also identified by DOI 10.1038/nrc2732.
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Abstract
Evolutionary patterns indicate that primordial p53 genes predated the appearance of cancer. Therefore, wild-type tumour suppressive functions and mutant oncogenic functions that give celebrity status to this gene family were probably co-opted from unrelated primordial activities. Is it possible to deduce what these early functions might have been? And might this knowledge provide a platform for therapeutic opportunities?
Medical subject headings
- Evolution, Molecular
- Genes, p53
- Tumor Suppressor Protein p53