Poor sensitivity of field rapid HIV testing: implications for mother-to-child transmission programme.
Level III
Where this comes from
- Record sourced from PubMed, PMID 19781042.
- Also identified by DOI 10.1111/j.1471-0528.2009.02357.x.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
We validated rapid HIV tests among pregnant women in a clinical setting. Field testing was performed using First Response 1,2,3 or Standard Diagnostic and Pareekshak tests. Results were confirmed by third generation HIV ELISA. Discordant or negative, specimens were confirmed by RNA PCR and a fourth generation ELISA test. Sensitivity and specificity were 94.5% (CI: 85.8-98.2) and 100% for First Response; 87.5% (CI: 46.7-99.3) and 100% (CI: 87.7-100%) for Standard Diagnostic and 90.2% (CI: 81.2-95.4) and 100% (CI: 98-100%) for Pareekshak. These sensitivities were lower than laboratory validation which approached 100%. The low-field sensitivity results have implications for Prevention of Mother-to-Child Transmission services.
Medical subject headings
- HIV Infections
- HIV-1
- Infectious Disease Transmission, Vertical
- Pregnancy Complications, Infectious