Endogenous neurotransmitter activates N-methyl-D-aspartate receptors on differentiating neurons in embryonic cortex.
basic_science · Level V
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- Record sourced from PubMed, PMID 1978317.
- Also identified by PMC identifier 54885.
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Abstract
Before synapses form in embryonic turtle cerebral cortex, an endogenous neurotransmitter activates N-methyl-D-aspartate (NMDA) channels on neurons in the cortical plate. Throughout cortical development, these channels exhibit voltage-dependent Mg2+ blockade and are antagonized by D-2-amino-5-phosphonovaleric acid, a selective NMDA receptor antagonist. The activation in situ of these nonsynaptic NMDA channels demonstrates a potential physiological substrate for control of early neuronal differentiation.
Medical subject headings
- Cerebral Cortex
- Glutamates
- Neurons
- Neurotransmitter Agents
- Receptors, N-Methyl-D-Aspartate