Treatment of drug-induced agranulocytosis with recombinant GM-CSF.
case_report · Level V
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Abstract
A 53-year male patient, treated for rheumatoid arthritis with sulphasalazine, developed a total agranulocytosis. When this state had prevailed for at least 10 d no bone marrow granulocyte progenitor cells were detectable. Intravenous GM-CSF treatment was initiated 5 d later, and the patient recovered within the next 6 d. GM-CSF treatment for severe agranulocytosis deserves further investigation.
Medical subject headings
- Agranulocytosis
- Granulocyte-Macrophage Colony-Stimulating Factor
- Sulfasalazine