PARylation: strengthening the connection between cancer and pluripotency.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19796612.
- Also identified by DOI 10.1016/j.stem.2009.09.002.
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Abstract
Pluripotency and tumorgenicity appear fundamentally linked. Recent investigations into the role of PARylation in chromatin remodeling (Ahel et al., 2009; Gottschalk et al., 2009), combined with the demonstration that p53 serves as a barrier to pluripotency (Banito et al., 2009), further strengthen this connection.
Medical subject headings
- Neoplasms
- Poly(ADP-ribose) Polymerases