Learning how to read ADP-ribosylation.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 19804746.
- Also identified by DOI 10.1016/j.cell.2009.09.018.
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Abstract
ADP-ribosylation is a posttranslational modification that is emerging as a broadly used mechanism to regulate the functions of proteins and their interactions. Recent findings by three groups (Ahel et al., 2009; Gottschalk et al., 2009; Timinszky et al., 2009) establish that proteins with macrodomains bind poly-ADP-ribose to mediate the cellular response to DNA damage.
Medical subject headings
- DNA Repair
- Poly Adenosine Diphosphate Ribose
- Protein Processing, Post-Translational
- Proteins