DNA double-strand breaks come into focus.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19804750.
- Also identified by DOI 10.1016/j.cell.2009.09.017.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The Mre11-Rad50-Nbs1 (MRN) complex senses DNA double-strand breaks and recruits different repair pathway and checkpoint proteins to break foci. Two new studies (Williams et al., 2009; Lloyd et al., 2009) identify Nbs1 as a key factor in this process and reveal how an N-terminal protein recruitment module in Nbs1 binds to different response factors through shared phosphopeptide motifs.
Medical subject headings
- Cell Cycle Proteins
- DNA Breaks, Double-Stranded
- DNA Repair
- Nuclear Proteins
- Schizosaccharomyces pombe Proteins