Fast screening of protein surfaces using geometric invariant fingerprints.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 19805347.
- Also identified by DOI 10.1073/pnas.0906146106 and PMC identifier 2757799.
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Abstract
We develop a rapid and efficient method for the comparison of protein local surface similarities using geometric invariants (fingerprints). By combining fast fingerprint comparison with explicit alignment, we successfully screen the entire Protein Data Bank for proteins that possess local surface similarities. Our method is independent of sequence and fold similarities, and has potential application to protein structure annotation and protein-protein interface design.
Medical subject headings
- Proteins