Does hypothalamic inflammation cause obesity?
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 19808014.
- Also identified by DOI 10.1016/j.cmet.2009.09.003.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Obesity-induced inflammation causes cellular resistance to both insulin and leptin. In this issue, Brüning and colleagues (Kleinridders et al., 2009) add to growing evidence that this response occurs in the hypothalamus, as well as in peripheral tissues, which helps to explain how high-fat feeding induces a gradual increase in defended body weight.
Medical subject headings
- Dietary Fats
- Hypothalamus
- Obesity