A new wrinkle in the fold: hepcidin links inflammation to the unfolded protein response.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 19808016.
- Also identified by DOI 10.1016/j.cmet.2009.09.005.
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Abstract
The unfolded protein response (UPR) coordinates translational and transcriptional changes triggered by unfolded proteins within the endoplasmic reticulum. Two recent papers (Oliveira et al., 2009; Vecchi et al., 2009) show that the UPR modulates transcription of the hormone hepcidin, which controls plasma iron levels and perhaps innate immunity.
Medical subject headings
- Antimicrobial Cationic Peptides
- Inflammation
- Unfolded Protein Response