Preserving fertility during cancer treatment.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19812566.
- Also identified by DOI 10.1038/nm1009-1124 and PMC identifier 3124896.
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Abstract
Imatinib (trade name Gleevec) preserves fertility in female mice treated with the common chemotherapeutic agent cisplatin. Imatinib seems to block an apoptotic pathway activated by cisplatin in ovarian germ cells (pages 1179– 1185). The findings could lead to new ways to protect germ cells from the damaging effects of cancer treatment.
Medical subject headings
- Infertility, Female
- Piperazines
- Primary Ovarian Insufficiency
- Pyrimidines