The R753Q polymorphism abrogates toll-like receptor 2 signaling in response to human cytomegalovirus.
basic_science · Level V
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- Record sourced from PubMed, PMID 19814623.
- Also identified by DOI 10.1086/644501 and PMC identifier 2761976.
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Abstract
Toll-like receptor 2 (TLR2) serves as a pattern recognition receptor that signals the presence of cytomegalovirus. Herein, we report that R753Q polymorphism paralyzes TLR2-mediated immune signaling in cells exposed to cytomegalovirus glycoprotein B. This immunologic impairment could serve as a biologic mechanism underlying the association between the TLR2 R753Q polymorphism and cytomegalovirus disease in humans.
Medical subject headings
- Cytomegalovirus
- Polymorphism, Genetic
- Toll-Like Receptor 2