Very late-onset group B Streptococcus meningitis, sepsis, and systemic shigellosis due to interleukin-1 receptor-associated kinase-4 deficiency.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 19814626.
- Also identified by DOI 10.1086/630206.
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Abstract
We describe a child with very late-onset group B Streptococcus sepsis and meningitis, systemic shigellosis, and chronic osteomyelitis. Peripheral blood cells obtained from the patient and her brother did not respond to stimulation with either interleukin-1beta or lipopolysaccharide. Sequencing of the interleukin-1 receptor-associated kinase-4 gene revealed 2 novel mutations.
Medical subject headings
- Dysentery, Bacillary
- Interleukin-1 Receptor-Associated Kinases
- Meningitis
- Sepsis
- Streptococcus agalactiae