The complex field of interplay between vasoactive agents.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 19829312.
- Also identified by DOI 10.1038/ki.2009.335.
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Abstract
Lai et al. provide important new information regarding the interaction between the sympathetic and renin-angiotensin systems in the regulation of glomerular afferent arteriolar contractility. Their study demonstrates a calcium-independent enhanced contractile response to angiotensin II following norepinephrine administration. The interplay between the norepinephrine- and angiotensin II-stimulated pathways could potentially be important in physiological as well as pathophysiological situations with increased sympathetic nervous system activity, such as hypertension.
Medical subject headings
- Angiotensin II
- Calcium Signaling
- Kidney
- Norepinephrine
- Renal Circulation
- Vasoconstriction