High concentrations of interleukin 15 in breast milk are associated with protection against postnatal HIV transmission.
case_control · Level III
Where this comes from
- Record sourced from PubMed, PMID 19835475.
- Also identified by DOI 10.1086/644603 and PMC identifier 2811259.
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Abstract
Given the central role that interleukin 15 (IL-15) plays in human immunodeficiency virus (HIV) immunity, we hypothesized that IL-15 in breast milk may protect against postnatal HIV transmission. In a nested case-control study, we compared breast milk IL-15 levels in 22 HIV-infected women who transmitted HIV to their infants to those in 72 nontransmitters. Samples were collected in the first month of life, prior to HIV infection. IL-15 concentrations were associated with a decreased risk of HIV transmission in unadjusted analysis and after adjusting for milk viral load, CD4 cell count, and other cytokines in breast milk. IL-15-mediated immunity may protect against HIV transmission during breast-feeding.
Medical subject headings
- Breast Feeding
- HIV Infections
- Infectious Disease Transmission, Vertical
- Interleukin-15
- Milk, Human