Ferrying wingless across the synaptic cleft.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19837027.
- Also identified by DOI 10.1016/j.cell.2009.09.032.
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Abstract
Secreted Wnt morphogens mediate cell-cell communication, but the mechanism of Wnt transfer between cells is unknown. Korkut et al. (2009) report that the transmembrane protein Evi is a versatile carrier that guides Wingless to presynaptic terminals of motor neurons and then escorts it across the synaptic cleft. In postsynaptic muscles, Evi promotes Frizzled-2 trafficking.
Medical subject headings
- Drosophila
- Synapses