Structure casts light on mtDNA replication.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19837028.
- Also identified by DOI 10.1016/j.cell.2009.09.030.
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Abstract
In this issue, Lee et al. (2009) present a crystal structure of the human mitochondrial DNA polymerase (POLgamma). The structure of this heterotrimeric enzyme lays a foundation for understanding how POLgamma mutations cause human mitochondrial disease and why some antiviral nucleoside analogs cause cellular toxicity.
Medical subject headings
- DNA Replication
- DNA, Mitochondrial
- DNA-Directed DNA Polymerase