A chemical platform for improved induction of human iPSCs.
basic_science · Level V
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- Record sourced from PubMed, PMID 19838168.
- Also identified by DOI 10.1038/nmeth.1393 and PMC identifier 3724527.
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Abstract
The slow kinetics and low efficiency of reprogramming methods to generate human induced pluripotent stem cells (iPSCs) impose major limitations on their utility in biomedical applications. Here we describe a chemical approach that dramatically improves (200-fold) the efficiency of iPSC generation from human fibroblasts, within seven days of treatment. This will provide a basis for developing safer, more efficient, nonviral methods for reprogramming human somatic cells.
Medical subject headings
- Cell Differentiation
- Induced Pluripotent Stem Cells