Polymeric nanoparticle-based activatable near-infrared nanosensor for protease determination in vivo.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19842672.
- Also identified by DOI 10.1021/nl902709m and PMC identifier 3618996.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
We report here a new protease activatable strategy based on a polymer nanoparticle platform. This nanosensor delivers chemically labeled matrix metalloproteinase (MMP)-activatable fluorogenic peptides to the specific MMPs of interest in vivo. Intravenous administration of the nanosensor in an MMP-positive SCC-7 xenograft tumor and a colon cancer mouse model verified the enzyme specificity of the nanosensor in vivo. The design platform of the nanosensor is flexible and can be fine-tuned for a wide array of applications such as the detection of biomarkers, early diagnosis of disease, and monitoring therapeutic efficacy.
Medical subject headings
- Biomarkers, Tumor
- Colonic Neoplasms
- Fluorescent Dyes
- Matrix Metalloproteinases
- Nanotechnology
- Polymers
- Spectroscopy, Near-Infrared