Hijacking the chromatin remodeling machinery: impact of SWI/SNF perturbations in cancer.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 19843852.
- Also identified by DOI 10.1158/0008-5472.CAN-09-2166 and PMC identifier 3272668.
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Abstract
There is increasing evidence that alterations in chromatin remodeling play a significant role in human disease. The SWI/SNF chromatin remodeling complex family mobilizes nucleosomes and functions as a master regulator of gene expression and chromatin dynamics whose functional specificity is driven by combinatorial assembly of a central ATPase and association with 10 to 12 unique subunits. Although the biochemical consequence of SWI/SNF in model systems has been extensively reviewed, the present article focuses on the evidence linking SWI/SNF perturbations to cancer initiation and tumor progression in human disease.
Medical subject headings
- Chromatin
- Chromosomal Proteins, Non-Histone
- Neoplasms
- Transcription Factors