Neuropsychological effects of carbamazepine and phenytoin: a reanalysis.
retrospective_cohort · Level III
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- Record sourced from PubMed, PMID 1985279.
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Abstract
We previously reported that carbamazepine had fewer adverse neuropsychological effects than phenytoin, but it is now clear that our patients had much higher phenytoin than carbamazepine serum levels. When persons with high initial phenytoin levels were excluded, the statistical significance of all neuropsychological differences between the drugs disappeared.
Medical subject headings
- Carbamazepine
- Phenytoin
- Psychotropic Drugs