Enhancing cancer vaccine efficacy via modulation of the tumor microenvironment.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 19861446.
- Also identified by DOI 10.1158/1078-0432.CCR-09-2256.
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Abstract
The development of therapeutic cancer vaccines is impacted by immunosuppressive elements in the tumor microenvironment. Most immunogenic cancer proteins are "self," therefore, peripheral tolerance contributes substantially to tumor immune escape. Transforming growth factor beta (TGFbeta) actively modulates both inflammation and tolerance induction. Combining vaccination with agents that disarm TGFbeta will enhance vaccine efficacy.
Medical subject headings
- Neoplasms
- Transforming Growth Factor beta
- Tumor Escape